An Hemostatic Defect Associated with Dextran Infusion

Summary An hitherto undescribed hemostatic defect has been observed in normal subjects after infusion of dextran. This defect was characterized principally by a prolonged bleeding time. It was possible to produce this defect in all subjects in whom sufficient dextran was infused. The amount of 6% dextran required to produce this defect varied from 1000 to 6500 ml. Changes in plasma coagulation factors were minor and not sufficient to cause a prolonged bleeding time. The clinical significance of the hemostatic defect requires investigation.