Synthesis of New Cephamycin Derivatives and a Novel Rearrangement between Isothiazolethioacetamides and 1, 3-Dithietanecarboxamides

A novel intramolecular rearrangement of isothiazolethioacetamides into 1, 3-dithietanecarboxamides is described, together with the synthesis of a new cephamycin derivative (YM-09330) having a 1, 3-dithietane structure at the 7β-position. This compound showed strong antibacterial activity, especially...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1980/09/25, Vol.28(9), pp.2629-2636
Hauptverfasser:	IWANAMI, MASARU, MAEDA, TETSUYA, FUJIMOTO, MASAHARU, NAGANO, YOSHINOBU, NAGANO, NORIAKI, YAMAZAKI, ATSUKI, SHIBANUMA, TADAO, TAMAZAWA, KAZUHARU, YANO, KUNIICHIRO
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides Bacteria - drug effects Cephalosporins - chemical synthesis Cephamycins - chemical synthesis Cephamycins - pharmacology Chemical Phenomena Chemistry Heterocyclic Compounds interconversion Thiazoles Thioacetamide - analogs & derivatives
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A novel intramolecular rearrangement of isothiazolethioacetamides into 1, 3-dithietanecarboxamides is described, together with the synthesis of a new cephamycin derivative (YM-09330) having a 1, 3-dithietane structure at the 7β-position. This compound showed strong antibacterial activity, especially against gram-negative organisms.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.28.2629