Microarray-Assisted High-Throughput Identification of a Cell-Permeable Small-Molecule Binder of 14-3-3 Proteins
The way to a 14‐3‐3 binder: A fragment‐based combinatorial small‐molecule microarray generates affinity‐based fingerprints of the 14‐3‐3σ protein. One small molecule (see picture; in red box) that disrupts the 14‐3‐3/protein interaction (green/blue) has been identified. The compound is cell‐permeabl...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2010-09, Vol.49 (37), p.6528-6532 |
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| container_issue | 37 |
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| container_title | Angewandte Chemie (International ed.) |
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| creator | Wu, Hao Ge, Jingyan Yao, Shao Q |
| description | The way to a 14‐3‐3 binder: A fragment‐based combinatorial small‐molecule microarray generates affinity‐based fingerprints of the 14‐3‐3σ protein. One small molecule (see picture; in red box) that disrupts the 14‐3‐3/protein interaction (green/blue) has been identified. The compound is cell‐permeable and possesses both in vitro and in‐cell activities. |
| doi_str_mv | 10.1002/anie.201003257 |
| format | Article |
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| ispartof | Angewandte Chemie (International ed.), 2010-09, Vol.49 (37), p.6528-6532 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Animals Cell Line combinatorial chemistry fragment-based screening High-Throughput Screening Assays - methods Humans microarrays Molecular Structure Protein Array Analysis - methods Protein Isoforms - metabolism protein-protein interactions proteins |
| title | Microarray-Assisted High-Throughput Identification of a Cell-Permeable Small-Molecule Binder of 14-3-3 Proteins |
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