Viable Rat-Mouse Chimeras: Where Do We Go from Here?
In a tour-de-force study, Kobayashi et al. (2010) describe the first viable rat-mouse chimeras and demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gen...
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| Veröffentlicht in: | Cell 2010-09, Vol.142 (5), p.676-678 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | In a tour-de-force study, Kobayashi et al. (2010) describe the first viable rat-mouse chimeras and demonstrate that rat induced pluripotent stem (iPS) cells can rescue organ deficiency in mice. Rat iPS cells formed a fully functional pancreas when injected into mouse blastocysts lacking the Pdx1 gene required for pancreas formation. |
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| ISSN: | 0092-8674 1097-4172 |
| DOI: | 10.1016/j.cell.2010.08.021 |