Washout Rate of Cardiac Iodine-123 Metaiodobenzylguanidine is High in Chronic Heart Failure Patients With Central Sleep Apnea

Abstract Background The association between sleep-disordered breathing (SDB) assessed by polysomnography and cardiac sympathetic nerve activity (SNA) assessed by cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) imaging has not been investigated in patients with chronic heart failure (CHF). Met...

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Veröffentlicht in:	Journal of cardiac failure 2010-09, Vol.16 (9), p.728-733
Hauptverfasser:	Tamura, Akira, MD, Ando, Shinichi, MD, PhD, Goto, Yukie, MD, Kawano, Yoshiyuki, MD, Shinozaki, Kazuhiro, MD, Kotoku, Munenori, MD, Kadota, Junichi, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Iodobenzylguanidine Aged Cardiovascular central sleep apnea chronic heart failure Female Health Status Indicators Heart Failure - diagnosis Heart Failure - diagnostic imaging Heart Failure - physiopathology Humans Iodine-123 metaiodobenzylguanidine Male Middle Aged Multivariate Analysis Natriuretic Peptide, Brain - blood obstructive sleep apnea Polysomnography Prognosis Radionuclide Imaging Radiopharmaceuticals Regression Analysis Sleep Apnea, Central - physiopathology sleep-disordered breathing Statistics, Nonparametric Stroke Volume Sympathetic Nervous System Ventricular Function, Left washout rate, sympathetic nerve activity
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Zusammenfassung:	Abstract Background The association between sleep-disordered breathing (SDB) assessed by polysomnography and cardiac sympathetic nerve activity (SNA) assessed by cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) imaging has not been investigated in patients with chronic heart failure (CHF). Methods and Results We performed cardiac 123I-MIBG scintigraphy and overnight polysomnography in 59 patients with stable CHF. The patients were classified into the 3 groups: 19 with no or mild SDB (NM-SDB, apnea-hypopnea index
ISSN:	1071-9164 1532-8414
DOI:	10.1016/j.cardfail.2010.04.012