Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists

Potent and selective adenosine A 1 receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-10, Vol.20 (19), p.5891-5894
Hauptverfasser:	Griebenow, Nils, Bärfacker, Lars, Meier, Heinrich, Schneider, Dirk, Teusch, Nicole, Lustig, Klemens, Kast, Raimund, Kolkhof, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminopyrazole Adenosin A 1 receptor antagonist Adenosine A1 Receptor Antagonists - chemical synthesis Adenosine A1 Receptor Antagonists - chemistry Adenosine A1 Receptor Antagonists - pharmacokinetics Animals Biological and medical sciences Cardiovascular system Diuresis Heart failure Medical sciences Miscellaneous Natriuresis Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacokinetics Rats Rats, Wistar Receptor, Adenosine A1 - chemistry Receptor, Adenosine A1 - metabolism Structure-Activity Relationship Urinary system
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Beschreibung
Zusammenfassung:	Potent and selective adenosine A 1 receptor antagonists were disclosed. SAR and pharmacological profile of selected compounds were discussed.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2010.07.095