Pd(II)-Catalyzed Hydroxyl-Directed C−H Activation/C−O Cyclization: Expedient Construction of Dihydrobenzofurans

Pd(II)-Catalyzed Hydroxyl-Directed C−H Activation/C−O Cyclization: Expedient Construction of Dihydrobenzofurans

A Pd(II)-catalyzed C−H activation/C−O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.

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Veröffentlicht in:Journal of the American Chemical Society 2010-09, Vol.132 (35), p.12203-12205
Hauptverfasser: Wang, Xisheng, Lu, Yi, Dai, Hui-Xiong, Yu, Jin-Quan
Format: Artikel
Sprache:eng
Schlagworte:
Benzofurans - chemical synthesis
Benzofurans - chemistry
Catalysis
Cyclization
Hydroxides - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Palladium - chemistry
Stereoisomerism
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Zusammenfassung:A Pd(II)-catalyzed C−H activation/C−O cyclization reaction directed by a proximate hydroxyl group has been developed. This reaction provides a new method for constructing dihydrobenzofurans, including spirocyclic analogues, a process that is potentially applicable to natural product synthesis.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja105366u