Significance of Preoperative Evaluations of Tumor Necrosis Factor-Alpha, the Granulocyte/Lymphocyte Ratio and Their Correlation with Regard to Outcome in Gastric Cancer Patients

Significance of Preoperative Evaluations of Tumor Necrosis Factor-Alpha, the Granulocyte/Lymphocyte Ratio and Their Correlation with Regard to Outcome in Gastric Cancer Patients

Aim: In order to clarify the anti-cancer effects of tumor necrosis factor-α (TNFα), we examined the relationship between the preoperative evaluations of TNFα and the granulocyte/lymphocyte ratio (G/L ratio) in relation to outcome in gastric cancer patients. Materials and Methods: Peripheral blood sa...

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Veröffentlicht in:Digestive surgery 2010-01, Vol.27 (4), p.324-330
Hauptverfasser: Ubukata, Hideyuki, Konishi, Satoru, Nagata, Hiroyuki, Kasuga, Nobuhiro, Watanabe, Yoshinori, Goto, Yoshihisa, Nakada, Ichiro, Tabuchi, Takafumi
Format: Artikel
Sprache:eng
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Aged
Aged, 80 and over
Analysis of Variance
Biomarkers, Tumor - blood
Cohort Studies
Disease-Free Survival
Female
Follow-Up Studies
Gastrectomy - methods
Gastrectomy - mortality
Granulocytes - physiology
Humans
Kaplan-Meier Estimate
Lymphocytes - physiology
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Original Paper
Preoperative Care - methods
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Sensitivity and Specificity
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Survival Analysis
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha - blood
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Zusammenfassung:Aim: In order to clarify the anti-cancer effects of tumor necrosis factor-α (TNFα), we examined the relationship between the preoperative evaluations of TNFα and the granulocyte/lymphocyte ratio (G/L ratio) in relation to outcome in gastric cancer patients. Materials and Methods: Peripheral blood samples were taken within 1 week before curative gastrectomy for measurement of TNFα and the G/L ratio. Five-year survival was determined in 71 operative gastric cancer cases. Results: The 5-year survival of the high TNFα group (≧8,000 pg/ml ) was 64.1%, 29.0% for the low TNFα group (
ISSN:0253-4886
1421-9883
DOI:10.1159/000308461