Effect of Anti-Hyaluronidase Compounds upon the Response of the Rat to Pituitary Trophic Hormones

Summary Anti-hyaluronidase agents, i.e. phosphorylated hesperidin, d-alphatocopherol phosphate, and chrondroitin sulfate were shown to be capable of increasing the effectiveness of administered pituitary trophic hormones such as follicle stimulating hormone (FSH) and corticotrophin. A four-fold increase in effectiveness of FSH was attained when the hormone was administered together with the anti-hyaluronidase agents as compared to the injection of the gonadotrophin alone. A similar degree of enhancement was obtained with corticotrophin. The augmentation induced by the anti-hyaluronidase compounds is attributed to the decreased rate of absorption of the hormone from the site of injection.