Differential effects of various stimuli on AVP levels in blood and cerebrospinal fluid

Water deprivation, drinking water containing 2% NaCl, or sytemic injection with histamine or nicotine markedly increased plasma levels of vasopressin in rats. In contrast, none of the applied stimuli changed vasopressin levels in the CSF collected simultaneously from the same animal. These data sugg...

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Veröffentlicht in:	European journal of pharmacology 1980-01, Vol.68 (1), p.89-92
Hauptverfasser:	Mens, Wim B.J., Bouman, Henk J., Bakker, Els A.D., Van Wimersma Greidanus, Tjeerd B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - blood Arginine Vasopressin - cerebrospinal fluid Cerebrospinal fluid Histamine Histamine - pharmacology Male Nicotine Nicotine - pharmacology Rats Rats, Inbred Strains Saline Solution, Hypertonic - pharmacology Vasopressin Water Deprivation
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Beschreibung
Zusammenfassung:	Water deprivation, drinking water containing 2% NaCl, or sytemic injection with histamine or nicotine markedly increased plasma levels of vasopressin in rats. In contrast, none of the applied stimuli changed vasopressin levels in the CSF collected simultaneously from the same animal. These data suggest that the blood levels of vasopressin are controlled quite differently from CSF levels of this hormone.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(80)90067-9