New Prostacyclin Analogues

The highly active prostacyclin (1) cannot be used therapeutically owing to its extremely short half‐life (only 3 min in water at 37°C pH 7.5). Methyl esters of the three analogues having the partial structure (2), X = O,S, and NH, have now been synthesized from an industrially available starting com...

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Veröffentlicht in:	Angewandte Chemie International Edition 1980-01, Vol.19 (10), p.819-820
Hauptverfasser:	Bartmann, Wilhelm, Beck, Gerhard, Knolle, Jochen, Rupp, R. Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Epoprostenol Humans Platelet Aggregation - drug effects Prostaglandins, Synthetic - chemical synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The highly active prostacyclin (1) cannot be used therapeutically owing to its extremely short half‐life (only 3 min in water at 37°C pH 7.5). Methyl esters of the three analogues having the partial structure (2), X = O,S, and NH, have now been synthesized from an industrially available starting compound. The analogues exhibit interesting biological properties.
ISSN:	0570-0833 1433-7851 1521-3773
DOI:	10.1002/anie.198008191