Effect of Trypsin on Prothrombin.

Effect of Trypsin on Prothrombin.

Summary 1. Trypsin converts prothrombin into thrombin. Calcium and accessory clotting factors are not essential. Calcium does, however, accelerate the rate of thrombin formation but without affecting the thrombin yield. 2. Conversion of prothrombin by trypsin is incomplete. 3. Heparin, in low concen...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1953-11, Vol.84 (2), p.432-437
Hauptverfasser: Kleinfeld, George, Habif, David V.
Format: Artikel
Sprache:eng
Schlagworte:
Hemostatics
Humans
Old Medline
Prothrombin
Trypsin - pharmacology
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Zusammenfassung:Summary 1. Trypsin converts prothrombin into thrombin. Calcium and accessory clotting factors are not essential. Calcium does, however, accelerate the rate of thrombin formation but without affecting the thrombin yield. 2. Conversion of prothrombin by trypsin is incomplete. 3. Heparin, in low concentrations, can inhibit the clotting effect of trypsin by increasing plasma antithrombic activity.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-84-20670