Enzyme Inducing Effects of Phenobarbital on Nitrazepam Metabolism in Dogs

: A 6‐day peroral phenobarbital treatment of beagle dogs decreased clearly and significantly the mean AUC (1252±270 ng/ml/hr) of a single peroral dose of nitrazepam (1.5 mg/kg), as a sign of enzyme induction to one third (428 ±37 ng/ml/hr P

Bibliographische Detailangaben

Veröffentlicht in:	Acta pharmacologica et toxicologica 1980-09, Vol.47 (3), p.171-174
Hauptverfasser:	Eliander, H., Pekkarinen, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dogs enzyme induction Enzyme Induction - drug effects Female Kinetics Male Nitrazepam Nitrazepam - metabolism Nitrazepam - pharmacology phenobarbital Phenobarbital - pharmacology plasma
Online-Zugang:	Volltext
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