Enzyme Inducing Effects of Phenobarbital on Nitrazepam Metabolism in Dogs

Enzyme Inducing Effects of Phenobarbital on Nitrazepam Metabolism in Dogs

: A 6‐day peroral phenobarbital treatment of beagle dogs decreased clearly and significantly the mean AUC (1252±270 ng/ml/hr) of a single peroral dose of nitrazepam (1.5 mg/kg), as a sign of enzyme induction to one third (428 ±37 ng/ml/hr P

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Bibliographische Detailangaben
Veröffentlicht in:Acta pharmacologica et toxicologica 1980-09, Vol.47 (3), p.171-174
Hauptverfasser: Eliander, H., Pekkarinen, A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dogs
enzyme induction
Enzyme Induction - drug effects
Female
Kinetics
Male
Nitrazepam
Nitrazepam - metabolism
Nitrazepam - pharmacology
phenobarbital
Phenobarbital - pharmacology
plasma
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Beschreibung
Zusammenfassung:: A 6‐day peroral phenobarbital treatment of beagle dogs decreased clearly and significantly the mean AUC (1252±270 ng/ml/hr) of a single peroral dose of nitrazepam (1.5 mg/kg), as a sign of enzyme induction to one third (428 ±37 ng/ml/hr P
ISSN:0001-6683
1600-0773
DOI:10.1111/j.1600-0773.1980.tb01555.x