Petriellidium boydii infection of the sphenoid sinus

Petriellidium boydii infection of the sphenoid sinus in a previously healthy woman was initially diagnosed by immunofluorescent staining of biopsy tissue sections. The diagnosis was confirmed by demonstrating P. boydii precipitins in serum and by isolating the infecting fungus. Despite surgical drainage and intensive therapy with miconazole nitrate, the outcome, because of intracranial extension, was fatal.