An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions

An actin-binding protein from Acanthamoeba regulates actin filament polymerization and interactions

A protein has been purified from Acanthamoeba which, like cytochalasin B, caps the end of actin filaments normally favoured for monomer addition and inhibits the interactions of actin filaments. In addition, this ‘capping’ protein nucleates the polymerization of actin monomers and blocks the anneali...

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Veröffentlicht in:Nature (London) 1980-12, Vol.288 (5790), p.455-459
Hauptverfasser: Isenberg, Gerhard, Aebi, Ueli, Pollard, Thomas D
Format: Artikel
Sprache:eng
Schlagworte:
Actins - metabolism
Amoeba - analysis
Animals
Carrier Proteins - isolation & purification
Carrier Proteins - metabolism
Crystallography
Cytoskeleton - metabolism
Cytoskeleton - ultrastructure
Gels
Gelsolin
Humanities and Social Sciences
Macromolecular Substances
Microfilament Proteins
Molecular Weight
multidisciplinary
Science
Science (multidisciplinary)
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Beschreibung
Zusammenfassung:A protein has been purified from Acanthamoeba which, like cytochalasin B, caps the end of actin filaments normally favoured for monomer addition and inhibits the interactions of actin filaments. In addition, this ‘capping’ protein nucleates the polymerization of actin monomers and blocks the annealing of actin filament fragments.
ISSN:0028-0836
1476-4687
DOI:10.1038/288455a0