Copper-Catalyzed Highly Regioselective Oxidative CH Bond Amidation of 2-Arylpyridine Derivatives and 1-Methylindoles

Copper-Catalyzed Highly Regioselective Oxidative CH Bond Amidation of 2-Arylpyridine Derivatives and 1-Methylindoles

Copper(I) bromide‐catalyzed amidation of 2‐arylpyridine derivatives and 1‐methylindoles with a variety of amides was achieved by employing tert‐butyl peroxide (TBP) as oxidant. Aryl halides could be tolerated under the reaction conditions. Neither a special ligand nor a base was required for this am...

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Veröffentlicht in:Advanced synthesis & catalysis 2010-03, Vol.352 (4), p.632-636
Hauptverfasser: Shuai, Qi, Deng, Guojun, Chua, Zhijie, Bohle, D. Scott, Li, Chao-Jun
Format: Artikel
Sprache:eng
Schlagworte:
1-methylindoles
2-phenylpyridines
amidation
Amides
Aromatic compounds
Bonding
copper
Derivatives
Halides
Ligands
Peroxides
regioselectivity
Synthesis
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Zusammenfassung:Copper(I) bromide‐catalyzed amidation of 2‐arylpyridine derivatives and 1‐methylindoles with a variety of amides was achieved by employing tert‐butyl peroxide (TBP) as oxidant. Aryl halides could be tolerated under the reaction conditions. Neither a special ligand nor a base was required for this amidation process.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900775