Serum branched-chain amino acids in the diagnosis of hyperinsulinism in infancy

Fasting values of branched-chain amino acids (valine, leucine, and isoleucine) were measured by column chromatography in the sera of 27 normal infants and children, 15 days to 9 years of age, 14 children with documented ketotic hypoglycemia one to 7 years of age, and in 14 sera from six infants, 15...

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Veröffentlicht in:	The Journal of pediatrics 1980-12, Vol.97 (6), p.923-926
Hauptverfasser:	Chaussain, Jean-Louis, Georges, Pierre, Gendrel, Dominique, Donnadieu, Marcel, Job, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Branched-Chain - blood Blood Glucose - analysis Child, Preschool Fasting Humans Hydroxybutyrates - blood Hyperinsulinism - blood Hypoglycemia - blood Infant Infant, Newborn Infant, Newborn, Diseases - blood Insulin - blood
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Zusammenfassung:	Fasting values of branched-chain amino acids (valine, leucine, and isoleucine) were measured by column chromatography in the sera of 27 normal infants and children, 15 days to 9 years of age, 14 children with documented ketotic hypoglycemia one to 7 years of age, and in 14 sera from six infants, 15 days to 2 years of age, with documented hyperinsulinism. In normal children and those with ketotic hypoglycemia, each individual branched-chain amino acid and their sum were significantly negatively coreelated with blood sugar values ranging between 11 and 92 mg/dl ( P
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(80)80421-5