Shape Changes Induced by N-Terminal Platination of Ubiquitin by Cisplatin

The three-dimensional conformation of a protein is an important property and plays a key role in its biological activity. We show here that ion mobility-mass spectrometry (IM-MS) can be used to detect conformational changes in the protein ubiquitin in the gas phase induced by reaction with the antic...

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Veröffentlicht in:	Journal of the American Society for Mass Spectrometry 2010-07, Vol.21 (7), p.1097-1106
Hauptverfasser:	Williams, Jonathan P., Phillips, Hazel I.A., Campuzano, Iain, Sadler, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Animals Antineoplastic agents Binding sites Bioinformatics Biological Biological activity Biological and medical sciences Biotechnology Cattle Change detection Charge Chemistry Chemistry and Materials Science Cisplatin - chemistry Cisplatin - metabolism Digestion Drugs Energy of dissociation Erythrocytes - chemistry General aspects In vivo methods and tests Ionic mobility Ions Ions - chemistry Ions - metabolism Mass spectrometry Medical sciences Methionine Organic Chemistry Peptide Fragments - chemistry Peptide Fragments - metabolism Peptides Pharmacology. Drug treatments Platinum Protein Conformation Proteins Proteomics Scientific imaging Shedding Spectrometry, Mass, Electrospray Ionization - methods Spectroscopy Surgical implants Tandem Mass Spectrometry - methods Trypsin Trypsin - metabolism Ubiquitin - chemistry Ubiquitin - metabolism
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