Delivery of antiviral chemotherapeutic agents to neurons by retrograde axonal transport

It may be possible to eliminate herpes simplex or zoster viruses from the neurons of carriers by treatment with an antiviral chemotherapeutic agent such as adenine arabinoside, ribavirin or acyclovir, coupled to a compound such as horseradish peroxidase that undergoes retrograde axonal transport.

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Bibliographische Detailangaben
Veröffentlicht in:	Medical hypotheses 1980-08, Vol.6 (8), p.773-779
Hauptverfasser:	Fox, J.S., White, D.O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir adenine arabinoside Axonal Transport Chemical Phenomena Chemistry chemotherapy Guanine - analogs & derivatives Guanine - therapeutic use Herpes Simplex - drug therapy Herpes Zoster - drug therapy Herpesviruses horseradish peroxidase Horseradish Peroxidase - metabolism Horseradish Peroxidase - therapeutic use Humans latent infection neuron Peroxidases - therapeutic use retrograde axonal transport Ribavirin - therapeutic use Vidarabine - therapeutic use
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Beschreibung
Zusammenfassung:	It may be possible to eliminate herpes simplex or zoster viruses from the neurons of carriers by treatment with an antiviral chemotherapeutic agent such as adenine arabinoside, ribavirin or acyclovir, coupled to a compound such as horseradish peroxidase that undergoes retrograde axonal transport.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/0306-9877(80)90001-8