The placental transfer of betamethasone

The placental transfer of betamethasone

The plasma concentrations of betamethasone in a maternal peripheral vein (mv) and in the umbilical vein (uv) were measured at delivery in eleven patients after the administration of betamethasone phosphate equivalent to 8 mg betamethasone. Betamethasone concentrations were measured in plasma using a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of clinical pharmacology 1980-10, Vol.18 (3), p.245-247
Hauptverfasser: Petersen, M C, Nation, R L, Ashley, J J, McBride, W G
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Betamethasone - administration & dosage
Betamethasone - metabolism
Female
Humans
Injections, Intramuscular
Injections, Intravenous
Maternal-Fetal Exchange
Pregnancy
Time Factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The plasma concentrations of betamethasone in a maternal peripheral vein (mv) and in the umbilical vein (uv) were measured at delivery in eleven patients after the administration of betamethasone phosphate equivalent to 8 mg betamethasone. Betamethasone concentrations were measured in plasma using a specific and sensitive HPLC assay. The time interval between the last dose and delivery ranged from 56 min to 800 min and over this time period the mean plasma concentration ratio Cuv/Cmv was 0.28 +/- 0.04 (SD) and exhibited no time dependence.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00563006