Incorporation of 14C-mevalonate into biliary cholesterol and bile acids by perfused rat liver: Effect of plasma and individual lipoproteins
Effect of plasma and individual lipoproteins on the incorporation of 14C-mevalonate into biliary bile acids and cholesterol by perfused rat liver was investigated. Use of plasma free perfysate (instead of whole blood) gave similar rates of incorporation of 14 C-mevalonate into biliary bile acids, bu...
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Veröffentlicht in: | Steroids 1980-10, Vol.36 (4), p.497-505 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Effect of plasma and individual lipoproteins on the incorporation of
14C-mevalonate into biliary bile acids and cholesterol by perfused rat liver was investigated. Use of plasma free perfysate (instead of whole blood) gave similar rates of incorporation of
14 C-mevalonate into biliary bile acids, but showed a decrease in percent distribution in cholic acid and a increase in β-muricholic acid. Addition of VLDL (isolated from Zucker rats) into the plasma free perfusate caused a significant increase in the incorporation of the label into bile acids, but LDL and HDL had no effect. HDL caused an increase in biliary excretion of
14C-cholesterol. |
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ISSN: | 0039-128X 1878-5867 |
DOI: | 10.1016/0039-128X(80)90036-7 |