Cyclic AMP Enhancement of Depolarization‐Induced NAD(P)H Changes in Brain Cortical Slices

Cyclic AMP Enhancement of Depolarization‐Induced NAD(P)H Changes in Brain Cortical Slices

: The increased levels of NAD(P)H effected by electrical depolarization are markedly augmented in the presence of cyclic AMP, isoproterenol, or RO 20–1724, agents known to elevate cyclic AMP in rat brain slices. The data presented indicate that the cyclic AMP effect on an important component of inte...

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Veröffentlicht in:Journal of neurochemistry 1980-12, Vol.35 (6), p.1329-1334
Hauptverfasser: Keller, E., Cummins, J. T.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Cyclic AMP
Cyclic AMP - pharmacology
Depolarization
Electric Stimulation
In Vitro Techniques
Male
NAD - metabolism
NAD(P)H
NADP - metabolism
Oxidation-Reduction
Rats
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Zusammenfassung:: The increased levels of NAD(P)H effected by electrical depolarization are markedly augmented in the presence of cyclic AMP, isoproterenol, or RO 20–1724, agents known to elevate cyclic AMP in rat brain slices. The data presented indicate that the cyclic AMP effect on an important component of intermediate metabolism is not an enhancement of a basal response but a separate response that is activated by depolarization, is Ca2+–dependent, regulates cytochrome a‐a3 independently of its effects on NAD(P)H levels, and is dependent on a substrate other than glucose.
ISSN:0022-3042
1471-4159
DOI:10.1111/j.1471-4159.1980.tb09006.x