The role of calcium in the generation of intracellular SRS-A in passively sensitized human lung challenged with antigen

The role of calcium in the generation of intracellular SRS-A in passively sensitized human lung challenged with antigen

Summary Calcium deprivation inhibits the formation and subsequent release of SRS‐A as well as histamine from passively sensitized human lung fragments challenged with antigen. Antimycin A inhibits the release of histamine and SRS‐A in a dose dependant fashion, while causing a mild inhibition of SRS‐...

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Veröffentlicht in:Clinical allergy 1980-09, Vol.10 (5), p.565-573
Hauptverfasser: HUTCHCROFT, B. J., ORANGE, R. P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigens
Antimycin A - pharmacology
Calcium - deficiency
Calcium - pharmacology
Deoxyglucose - pharmacology
Guinea Pigs
Histamine Release
Humans
Immunization, Passive
SRS-A - biosynthesis
Temperature
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Zusammenfassung:Summary Calcium deprivation inhibits the formation and subsequent release of SRS‐A as well as histamine from passively sensitized human lung fragments challenged with antigen. Antimycin A inhibits the release of histamine and SRS‐A in a dose dependant fashion, while causing a mild inhibition of SRS‐A formation throughout the dose range studied. These data suggest that the influx of calcium is the critical event for the generation of SRS‐A within the cell.
ISSN:0954-7894
0009-9090
1365-2222
DOI:10.1111/j.1365-2222.1980.tb02138.x