Kanamycin ototoxicity and pigmentation in the guinea pig

Kanamycin ototoxicity and pigmentation in the guinea pig

Cochleas from albino and pigmented guinea pigs were examined histologically following chronic administration of Kanamycin. In pigmented animals, damage was concentrated amongst hair cells towards the base, but in albinos, hair cell damage was diffusely spread. These observations support suggestions...

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Veröffentlicht in:Hearing research 1980-10, Vol.3 (3), p.249-251
Hauptverfasser: Comis, S.D., Leng, G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
cochlear hair cell
guinea pig
Guinea Pigs
Hair Cells, Auditory - drug effects
Hair Cells, Auditory, Inner - drug effects
Kanamycin
Kanamycin - pharmacology
ototoxicity
pigmentation
Skin Pigmentation
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Beschreibung
Zusammenfassung:Cochleas from albino and pigmented guinea pigs were examined histologically following chronic administration of Kanamycin. In pigmented animals, damage was concentrated amongst hair cells towards the base, but in albinos, hair cell damage was diffusely spread. These observations support suggestions that melanin is implicated in Kanamycin ototoxicity.
ISSN:0378-5955
1878-5891
DOI:10.1016/0378-5955(80)90051-9