Pathologic Physiology of Mammalian Blood Platelet Utilizing P32 Tagged Rabbit Platelets.

Summary 1. Purified, unagglutinated platelet suspensions prepared from rabbit blood do incorporate radioactive phosphorus readily, and therefore lend themselves to life span studies in vivo. 2. These studies indicate that transfused rabbit radioactive platelets are rapidly removed from the peripheral blood and the radioactivity recovered in organs of the reticuloendothelial system, namely spleen, liver, lung and bone marrow. 3. The problem of viability of these platelets is discussed. The evidence suggests that damage has occurred during manipulation. 4. These observations are important primarily in demonstrating aspects of metabolism and destruction of platelets.