Diminished bacterial defences with intralipid

'Intralipid', a lipid emulsion used in parenteral nutrition, impaired bacterial clearance and enhanced bacterial virulence in mice. In addition it inhibited the chemotaxis of human neutrophils in vitro. Intralipid may enhance the risk of bacterial sepsis in certain patients.

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Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 1980-10, Vol.2 (8199), p.819-820
Hauptverfasser:	Fischer, G W, Hunter, K W, Wilson, S R, Mease, A D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - immunology Bacterial Infections - etiology Chemotaxis, Leukocyte Fat Emulsions, Intravenous - adverse effects Humans Mice Mice, Inbred Strains - immunology Mononuclear Phagocyte System Neutrophils - immunology Nutrition Disorders - therapy Risk Sepsis - etiology Streptococcal Infections - immunology Streptococcus agalactiae Virulence
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Beschreibung
Zusammenfassung:	'Intralipid', a lipid emulsion used in parenteral nutrition, impaired bacterial clearance and enhanced bacterial virulence in mice. In addition it inhibited the chemotaxis of human neutrophils in vitro. Intralipid may enhance the risk of bacterial sepsis in certain patients.
ISSN:	0140-6736