RESPIRATORY EFFECTS OF A NEW OPIATE ANALGESIC, R 39209, IN THE RABBIT: COMPARISON WITH FENTANYL

The respiratory effects of R 39209, a new short-acting analgesic, were studied and compared with those of fentanyl, in the rabbit. Minute volume, respiratory frequency and pH3PCO2 and standard bicarbonate of artcrialized venous blood were measumi R 39209 had an earlier peak effect and shorter durati...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1980-11, Vol.52 (11), p.1101-1106
Hauptverfasser:	BROWN, J.H., PLEUVRY, B.J., KAY, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alfentanil Analgesics, Opioid - pharmacology Animals Carbon Dioxide - blood Dose-Response Relationship, Drug Drug Administration Schedule Fentanyl - analogs & derivatives Fentanyl - pharmacology Kinetics Lung Volume Measurements Partial Pressure Rabbits Respiration - drug effects
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Zusammenfassung:	The respiratory effects of R 39209, a new short-acting analgesic, were studied and compared with those of fentanyl, in the rabbit. Minute volume, respiratory frequency and pH3PCO2 and standard bicarbonate of artcrialized venous blood were measumi R 39209 had an earlier peak effect and shorter duration of action than fentanyl, but otherwise the respiratory effects of the two drugs were similar. Fentanyl was between 2 and 3.5 times more potent than R 39209. Repeated doses of R 39209 produced reproducible peak effects wen when only 10 min was allowed between administranons.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/52.11.1101