The Emergence of ORG NC 45, 1- [(2β,3α, 5α,16β, 17β)-3, 17-BIS(Acetyloxy)-2-(1-Piperidinyl)-Androstan-16-YL]-1-Methylpiperidinium Bromide, from the Pancuronium Series

The Emergence of ORG NC 45, 1- [(2β,3α, 5α,16β, 17β)-3, 17-BIS(Acetyloxy)-2-(1-Piperidinyl)-Androstan-16-YL]-1-Methylpiperidinium Bromide, from the Pancuronium Series

A novel approach is described for obtaining a drug that will be a potent non-depolarizing neuromuscular blocking agent with he potential for a short duration of action and little cumulative effect. This approach led to the discovery of Org NC 45, from the pancuronium series.

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Bibliographische Detailangaben
Veröffentlicht in:British journal of anaesthesia : BJA 1980-01, Vol.52 (suppl-1), p.3S-6S
Hauptverfasser: Savage, D.S., Sleigh, T., Carlyle, I.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cats
Chemical Phenomena
Chemistry
Chemistry, Pharmaceutical
Humans
Neuromuscular Blocking Agents
Pancuronium - analogs & derivatives
Pancuronium - pharmacology
Rats
Structure-Activity Relationship
Vagus Nerve - drug effects
Vecuronium Bromide
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Beschreibung
Zusammenfassung:A novel approach is described for obtaining a drug that will be a potent non-depolarizing neuromuscular blocking agent with he potential for a short duration of action and little cumulative effect. This approach led to the discovery of Org NC 45, from the pancuronium series.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/52.suppl_1.3S