Neuronal Control of Acetylcholine Receptor turnover Rate at a Vertebrate Neuromuscular Junction

Neuronal Control of Acetylcholine Receptor turnover Rate at a Vertebrate Neuromuscular Junction

The turnover rate of acetylcholine receptors at neuromuscular junctions in mice increases progressively after denervation and, after 15 days, reaches a halftime of 30 $\pm $ 5 hours. Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1980-10, Vol.210 (4469), p.550-551
Hauptverfasser: Levitt, Tami A., Loring, Ralph H., Salpeter, Miriam M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bungarotoxins - metabolism
Cell membranes
Cholinergic receptors
Denervation
Innervation
Kinetics
Mice
Motor Neurons - physiology
Muscle Denervation
Muscles
Neuromuscular Junction - metabolism
Radioactive decay
Receptors
Receptors, Cholinergic - metabolism
Receptors, Nicotinic - metabolism
Synapses
Vertebrates
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Zusammenfassung:The turnover rate of acetylcholine receptors at neuromuscular junctions in mice increases progressively after denervation and, after 15 days, reaches a halftime of 30 $\pm $ 5 hours. Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic of extrajunctional receptors before innervation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7423205