The role of adjuvant therapy in Stage I ovarian cancer

Women with Stage I epithelial carcinoma of the ovary were initially treated by an extirpative operation and were subsequently randomized to either no further treatment, radiotherapy, or chemotherapy. Only two patients (6%) treated with chemotherapy developed recurrence, compared to five (17%) and se...

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Veröffentlicht in:	American journal of obstetrics and gynecology 1980-09, Vol.138 (2), p.139-145
Hauptverfasser:	Hreshchyshyn, Myroslaw M., Park, Robert C., Blessing, John A., Norris, Henry J., Levy, David, Lagasse, Leo D., Creasman, William T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - radiotherapy Adenocarcinoma, Mucinous - therapy Cystadenocarcinoma - therapy Endometriosis - therapy Female Humans Neoplasm Recurrence, Local - prevention & control Neoplasm Staging Ovarian Neoplasms - drug therapy Ovarian Neoplasms - radiotherapy
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Beschreibung
Zusammenfassung:	Women with Stage I epithelial carcinoma of the ovary were initially treated by an extirpative operation and were subsequently randomized to either no further treatment, radiotherapy, or chemotherapy. Only two patients (6%) treated with chemotherapy developed recurrence, compared to five (17%) and seven (30%) patients in the non-treatment and radioterapy regimens, respectively (P < 0.05). All patients, with the possible exception of those with Stage IA(1)g1, appeared to benefit from adjuvant chemotherapy compared to no treatment or radiotherapy.
ISSN:	0002-9378 1097-6868
DOI:	10.1016/0002-9378(80)90024-1