CHARACTERIZATION OF AROMATIC HEPTAENE MACROLIDE ANTIBIOTICS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
High performance liquid chromatographic (HPLC) procedures were utilized for the rapid and efficient separation and characterization of the aromatic heptaene macrolide group of antifungal antibiotics. The instrument utilized a 350nm phosphor converted ultraviolet detector and a μ Bondapak C18 column...
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| Veröffentlicht in: | Journal of antibiotics 1980, Vol.33(6), pp.591-599 |
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| container_end_page | 599 |
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| container_issue | 6 |
| container_start_page | 591 |
| container_title | Journal of antibiotics |
| container_volume | 33 |
| creator | MECHLINSKI, W. SCHAFFNER, C. P. |
| description | High performance liquid chromatographic (HPLC) procedures were utilized for the rapid and efficient separation and characterization of the aromatic heptaene macrolide group of antifungal antibiotics. The instrument utilized a 350nm phosphor converted ultraviolet detector and a μ Bondapak C18 column packing. Optimum resolution of eleven commercial aromatic heptaene macrolide preparations was obtained with solvent systems consisting of mixtures of acetonitrile and 0.05 M aqueous sodium citrate buffer, pH 5.3. The presence of two distinct types of aromatic heptaene macrolides with numerous well-defined individual components has been established. |
| doi_str_mv | 10.7164/antibiotics.33.591 |
| format | Article |
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The presence of two distinct types of aromatic heptaene macrolides with numerous well-defined individual components has been established.</description><subject>Antifungal Agents - analysis</subject><subject>Candicidin - analysis</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Organic Chemicals</subject><subject>Polyenes - analysis</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtP4zAUha3RIOjA_IGRkLyaXYsf8SNLE9LGmrYpISyYjWWnDgT1AXG7mH-PmVYVm3t1dc75dHUA-IXRSGCe3NjNrnPddtc1YUTpiKX4GxhgKfEQJzz9DgYIETyUkqAL8COEV4SooEKeg3MuU5okfAB8VqhKZXVe6b-q1uUclmOoqnIWjwwW-aJW-TyHM5VV5VTf5VDNa32ry6g-wNsnWOhJARd5NS6rmZpnOZzq-0d9B7PiP6OcVGpRPF2Bs9augv953JfgcZzXWTGclhOdqemwYVjET5EjLSXCMedRyolbUrpkHLWIedRa5pxrGRcoFahZthK1xFmcCiYTIRsbzZfg94H71m_f9z7szLoLjV-t7MZv98EIRiRHREQjORibfhtC71vz1ndr2_8zGJnPbs2Xbg2lJnYbQ9dH-t6t_fIUOZYZ9T8H_TXs7LM_6baPlJX_isQpl59YfhiRfnI1L7Y3fkM_AGdQix4</recordid><startdate>1980</startdate><enddate>1980</enddate><creator>MECHLINSKI, W.</creator><creator>SCHAFFNER, C. 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Antibiot.</addtitle><date>1980</date><risdate>1980</risdate><volume>33</volume><issue>6</issue><spage>591</spage><epage>599</epage><pages>591-599</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>High performance liquid chromatographic (HPLC) procedures were utilized for the rapid and efficient separation and characterization of the aromatic heptaene macrolide group of antifungal antibiotics. The instrument utilized a 350nm phosphor converted ultraviolet detector and a μ Bondapak C18 column packing. Optimum resolution of eleven commercial aromatic heptaene macrolide preparations was obtained with solvent systems consisting of mixtures of acetonitrile and 0.05 M aqueous sodium citrate buffer, pH 5.3. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1980, Vol.33(6), pp.591-599 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75286027 |
| source | J-STAGE Free; MEDLINE |
| subjects | Antifungal Agents - analysis Candicidin - analysis Chromatography, High Pressure Liquid - methods Organic Chemicals Polyenes - analysis |
| title | CHARACTERIZATION OF AROMATIC HEPTAENE MACROLIDE ANTIBIOTICS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY |
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