Reduction of N-acetyl-beta-glucosaminidase activity in the submaxillary glands of streptozotocin diabetic mice

Reduction of N-acetyl-beta-glucosaminidase activity in the submaxillary glands of streptozotocin diabetic mice

Streptozotocin diabetes strongly reduced the N-acetyl-β-glucosaminidase activity in the submaxillary glands of mice. A reciprocal change was observed between the enzyme activity and blood sugar in diabetes. Insulin treatment of the diabetic mice returned the reduced activity to the normal level. Iso...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 1980, Vol.88 (2), p.613-615
Hauptverfasser: Hatakeyama, K, Hiramatsu, M, Minami, N
Format: Artikel
Sprache:eng
Schlagworte:
Acetylglucosaminidase - metabolism
Animals
Blood Glucose - metabolism
Diabetes Mellitus, Experimental - enzymology
diet-related diseases
Female
Hexosaminidases - metabolism
human nutrition
Kinetics
Liver - enzymology
Mice
Mice, Inbred ICR
Organ Specificity
Parotid Gland - enzymology
Sublingual Gland - enzymology
Submandibular Gland - enzymology
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Zusammenfassung:Streptozotocin diabetes strongly reduced the N-acetyl-β-glucosaminidase activity in the submaxillary glands of mice. A reciprocal change was observed between the enzyme activity and blood sugar in diabetes. Insulin treatment of the diabetic mice returned the reduced activity to the normal level. Isoelectric focusing analysis showed that the submaxillary gland enzyme was composed of two isozymes having isoelectric points (pl) of 4.8 and 8.8. Only the pl 8.8 isozyme was affected by the diabetes.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a133011