The Significance of Cell Types in Bronchogenic Carcinoma

This report is based on a study of 1,000 cases of proved bronchogenic carcinoma which were observed at the Mayo Clinic. The cell type of the tumors was as follows: small cell carcinoma in 90 cases (9 per cent), adenocarcinoma in 137 cases (13.7 per cent), large cell carcinoma in 378 cases (37.8 per...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chest 1953-06, Vol.23 (6), p.621-633
Hauptverfasser: MOERSCH, HERMAN J., MCDONALD, JOHN R.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This report is based on a study of 1,000 cases of proved bronchogenic carcinoma which were observed at the Mayo Clinic. The cell type of the tumors was as follows: small cell carcinoma in 90 cases (9 per cent), adenocarcinoma in 137 cases (13.7 per cent), large cell carcinoma in 378 cases (37.8 per cent), and squamous cell carcinoma in 395 cases (39.5 per cent). Small cell carcinomas and squamous cell carcinomas occur much more frequently in men than in women. The ratio of males to females was 29:1 in the 90 cases of small cell carcinoma and 25.3:1 in the 395 cases of squamous cell carcinoma. The difference in the sexual incidence was not so great in the cases of adenocarcinoma or large cell carcinoma. The ratio of males to females was 3.4:1 in the 137 cases of adenocarcinoma and slightly less than 6:1 in the 378 cases of large cell carcinoma. The average age of the patients was slightly lower in the cases of small cell carcinoma than it was in cases of the other types of tumor. The duration of symptoms was shorter in the cases of small cell carcinoma than it was in cases of the other types of tumor. In all of the cases of small cell carcinoma, the patients had symptoms that were referable to the thorax. Such symptoms were not present in all of the cases of the other types of carcinoma. With the exceptions noted, the symptoms were essentially the same in all cases. Roentgenographic examination of the thorax disclosed an abnormality in all but 12 of the entire series of 1,000 cases. Bronchoscopy was not performed in all of the cases in the respective groups, but it was a very effective diagnostic procedure in cases in which the tumor arose from the central portion of the lung, that is, in cases of small cell carcinoma and in cases of squamous cell carcinoma. Cytologic examination of the sputum or bronchial secretions was more effective in the cases of small cell carcinoma and least effective in the cases of adenocarcinoma. The results of surgical treatment were more satisfactory in cases of squamous cell carcinoma than they were in cases of the other types of carcinoma. The results of surgical treatment were least satisfactory in the cases of small cell carcinoma.
ISSN:0096-0217
0012-3692
2589-3890
1931-3543
DOI:10.1378/chest.23.6.621