Genetic polymorphism of a serum euglobulin of chickens which binds to antigen-antibody complexes

Binding of a euglobulin from normal chicken serum to precipitating HSA anti-HSA complexes has been demonstrated. The binding appeared specific for the Fc-fragment of chicken antibody since it was not detected with rabbit Ag-Ab complexes. Two allelic allotypic markers of the euglobulin under genetic...

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Veröffentlicht in:	Immunogenetics (New York) 1980-01, Vol.10 (1), p.83-92
Hauptverfasser:	Ivanyi, J, Tempelis, C.H
Format:	Artikel
Sprache:	eng
Schlagworte:	animal breeding animal genetics Animals Antigen-Antibody Complex Binding Sites Chemical Precipitation Chickens Chromatography, Agarose Immunoglobulin Allotypes - genetics Lipoproteins Polymorphism, Genetic Rabbits Serum Albumin - immunology Serum Globulins - genetics Serum Globulins - immunology Serum Globulins - isolation & purification
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Beschreibung
Zusammenfassung:	Binding of a euglobulin from normal chicken serum to precipitating HSA anti-HSA complexes has been demonstrated. The binding appeared specific for the Fc-fragment of chicken antibody since it was not detected with rabbit Ag-Ab complexes. Two allelic allotypic markers of the euglobulin under genetic control from one locus (E-1) were found in chickens from two inbred strains. E-1 alleles segregated independently from those controlled by the B (major histocompatibility), M-1 and G-1 (Ig allotype) loci. Partially purified E-1 had a sedimentation coefficient of 15.6 S. and beta-globulin electrophoretic mobility.
ISSN:	0093-7711 1432-1211
DOI:	10.1007/BF01561554