Measurement of Pilocarpine and Its Degradation Products by High-Performance Liquid Chromatography

An assay method for pilocarpine using reversed-phase high-performance liquid chromatography is presented. This method also measures isopilocarpine, the stereoisomer of pilocarpine, and the degradation products pilocarpic acid and isopilocarpic acid. Maximum sensitivity was obtained with optical abso...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1980-09, Vol.69 (9), p.1096-1097
Hauptverfasser:	O'Donnell, James J., Sandman, Robert, Drake, Michael V.
Format:	Artikel
Sprache:	eng
Schlagworte:	and isopilocarpic acid Chromatography, High Pressure Liquid - methods Drug Stability high-performance liquid chromatographic analysis High-performance liquid chromatography-analysis High-performance liquid chromatography—analysis, pilocarpine, isopilocarpine, pilocarpic acid, and isopilocarpic acid isopilocarpine Ophthalmic drugs-pilocarpine Ophthalmic drugs—pilocarpine, high-performance liquid chromatographic analysis pilocarpic acid pilocarpine Pilocarpine - analysis Pilocarpine-reversed-phase high-performance liquid chromatographic analysis
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Beschreibung
Zusammenfassung:	An assay method for pilocarpine using reversed-phase high-performance liquid chromatography is presented. This method also measures isopilocarpine, the stereoisomer of pilocarpine, and the degradation products pilocarpic acid and isopilocarpic acid. Maximum sensitivity was obtained with optical absorbance at 216nm.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600690930