Antibiotics as inhibitors of enkephalin degradation by human brain

Antibiotics as inhibitors of enkephalin degradation by human brain

The effects of several antibiotics on a soluble, human brain enzyme that degrades Met-enkephalin by cleavage of the N-terminal Tyr-Gly bond were studied. Bacitracin (IC 50 = 10 μM) and Puromycin (IC 50 = 1 μM) inhibited cleavage of Tyr from Met-enkephalin; chloramphenicol and penicillin G failed to...

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Veröffentlicht in:Pharmacological research communications 1980-06, Vol.12 (6), p.575-580
Hauptverfasser: Traficante, L.J., Siekierski, J., Rotrosen, J., Gershon, S.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - pharmacology
Biotransformation
Brain - drug effects
Brain - metabolism
Corpus Striatum - metabolism
Depression, Chemical
Endorphins - metabolism
Enkephalins - metabolism
Humans
In Vitro Techniques
Time Factors
Tyrosine - metabolism
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Zusammenfassung:The effects of several antibiotics on a soluble, human brain enzyme that degrades Met-enkephalin by cleavage of the N-terminal Tyr-Gly bond were studied. Bacitracin (IC 50 = 10 μM) and Puromycin (IC 50 = 1 μM) inhibited cleavage of Tyr from Met-enkephalin; chloramphenicol and penicillin G failed to inhibit enzyme activity at concentrations up to 100 μM.
ISSN:0031-6989
1879-2936
DOI:10.1016/S0031-6989(80)80143-3