Is gastrin releasing peptide mammalian bombesin?

Is gastrin releasing peptide mammalian bombesin?

Mammalian gastrin releasing peptide, similar to frog skin bombesin lowers body temperature and increases plasma levels of epinephrine and glucose. Both peptides produce stereotypic scratching behavior in rats. Similarity of biological responses to these peptides and their common C-terminal decapepti...

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Veröffentlicht in:Life sciences (1973) 1980-01, Vol.27 (2), p.125-128
Hauptverfasser: Brown, Marvin, Märki, Walter, Rivier, Jean
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
Anura
Blood Glucose - metabolism
Body Temperature - drug effects
Bombesin - administration & dosage
Bombesin - physiology
Cisterna Magna
Dose-Response Relationship, Drug
Epinephrine - blood
Gastrin-Releasing Peptide
Gastrins - metabolism
Injections
Injections, Intraventricular
Male
Peptides - physiology
Rats
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Zusammenfassung:Mammalian gastrin releasing peptide, similar to frog skin bombesin lowers body temperature and increases plasma levels of epinephrine and glucose. Both peptides produce stereotypic scratching behavior in rats. Similarity of biological responses to these peptides and their common C-terminal decapeptide homology supports the concept that gastrin releasing peptide is a mammalian bombesin.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(80)90453-1