Studies on Phenylpyruvic Oligophrenia. Phenylpyruvic Acid Content of Blood

Studies on Phenylpyruvic Oligophrenia. Phenylpyruvic Acid Content of Blood

Summary Phenylpyruvic acid was demonstrated in the blood of 39 patients affected with phenylpyruvic oligophrenia. The values ranged from 0.31 to 1.78 mg per 100 ml of plasma. A significant increase of phenylketonemia was observed following ingestion of DL-phenylalanine, the D form causing considerab...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1952-12, Vol.81 (3), p.715-720
1. Verfasser: Jervis, George A.
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Humans
Intellectual Disability
Old Medline
Phenylketonurias
Phenylpyruvic Acids - blood
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Zusammenfassung:Summary Phenylpyruvic acid was demonstrated in the blood of 39 patients affected with phenylpyruvic oligophrenia. The values ranged from 0.31 to 1.78 mg per 100 ml of plasma. A significant increase of phenylketonemia was observed following ingestion of DL-phenylalanine, the D form causing considerably greater increase than the L isomer. Feeding of phenylpyruvic acid resulted in a sharp increase of phenylketonemia. The significance of these findings is briefly discussed.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-81-19998