3H-imipramine binding in neuronal and glial fractions of horse striatum

3H-imipramine binding in neuronal and glial fractions of horse striatum

The glial fraction prepared from horse striatum contained less than 20% of the specific high affinity 3H-imipramine binding sites found in the neuronal fraction prepared from the same tissue. The binding in the glial fraction was considered to result from minor cross-contamination of the two fractio...

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Veröffentlicht in:European journal of pharmacology 1980-06, Vol.64 (2), p.191-194
Hauptverfasser: Briley, Michael S., Fillion, Gilles, Beaudoin, Dominique, Fillion, Marie-Paule, Langer, Salomon Z.
Format: Artikel
Sprache:eng
Schlagworte:
3H-Imipramine binding
Animals
Antidepressants
Binding Sites
Corpus Striatum - metabolism
Depression
Glial fraction
Horses
Imipramine - metabolism
In Vitro Techniques
Neuroglia - metabolism
Neuronal fraction
Neurons - metabolism
Receptors, Serotonin - metabolism
Tritium
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Zusammenfassung:The glial fraction prepared from horse striatum contained less than 20% of the specific high affinity 3H-imipramine binding sites found in the neuronal fraction prepared from the same tissue. The binding in the glial fraction was considered to result from minor cross-contamination of the two fractions. It is thus conclude that there is probably no specific 3H-imipramine binding in glial cells.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(80)90046-1