Effects of Intranasal Administration of Hormonal Steroids on Serum Testosterone and Spermatogenesis in Rhesus Monkey (Macaca mulatta)

Spraying estradiol-17Î², progesterone or norethisterone intranasally in adult male rhesus monkeys (7.5-11 kg BW) at a daily dose of 30 Âµg/day for a period of 60 days resulted in a decrease of testicular size, arrest of spermatogenesis and a significant reduction in serum levels of testosterone. No...

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Veröffentlicht in:	Biology of reproduction 1980-05, Vol.22 (4), p.935-940
Hauptverfasser:	Anand Kumar, T C, Sehgal, A, David, G F, Bajaj, J S, Prasad, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Estradiol - administration & dosage Haplorhini Hydrocortisone - blood Macaca mulatta Male Norethindrone - blood Progesterone - administration & dosage Spermatogenesis - drug effects Testis - anatomy & histology Testis - drug effects Testosterone - blood
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Beschreibung
Zusammenfassung:	Spraying estradiol-17Î², progesterone or norethisterone intranasally in adult male rhesus monkeys (7.5-11 kg BW) at a daily dose of 30 Âµg/day for a period of 60 days resulted in a decrease of testicular size, arrest of spermatogenesis and a significant reduction in serum levels of testosterone. No changes were observed in the solvent-treated controls.
ISSN:	0006-3363 1529-7268
DOI:	10.1095/biolreprod22.4.935