Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism

The activity in two assay systems of guanine nucleotide regulatory protein was significantly lower in red cells from pseudohypoparathyroid patients compared to that of normal subjects. The results support the hypothesis that deficient activity of the guanine nucleotide regulatory protein is the mole...

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Veröffentlicht in:	Biochemical and biophysical research communications 1980-06, Vol.94 (4), p.1319-1324
Hauptverfasser:	Levine, M.A., Downs, R.W., Singer, M., Marx, S.J., Aurbach, G.D., Spiegel, A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Erythrocyte Membrane - metabolism Erythrocytes - metabolism GTP-Binding Proteins Guanine Nucleotides - blood Guanine Nucleotides - deficiency Guanine Nucleotides - isolation & purification Humans Macromolecular Substances Pseudohypoparathyroidism - blood Receptors, Cell Surface - blood Receptors, Cell Surface - deficiency Receptors, Cell Surface - isolation & purification Solubility
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Zusammenfassung:	The activity in two assay systems of guanine nucleotide regulatory protein was significantly lower in red cells from pseudohypoparathyroid patients compared to that of normal subjects. The results support the hypothesis that deficient activity of the guanine nucleotide regulatory protein is the molecular basis for hormone resistance in this inherited disorder.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(80)90563-X