PATHOPHYSIOLOGY OF THALASSEMIA

The clinical manifestations in homozygous thalassemia may be attributed to the defect in hemoglobin synthesis (Figure 16). It is best typified by beta thalassemia, where excess alpha chains accumulate to form intracytoplasmic erythrocytic inclusions. This leads to anemia, bone marrow hyperplasia, os...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 1980-05, Vol.344 (1), p.284-304
1. Verfasser:	Zaino, Edward C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow - pathology Erythrocyte Aging Erythrocytes - metabolism Erythrocytes - ultrastructure Erythropoiesis Hemoglobins - biosynthesis Hemosiderosis - etiology Hemosiderosis - pathology Humans Hyperplasia Inclusion Bodies - ultrastructure Osteoporosis - etiology Osteoporosis - pathology Peptide Fragments Thalassemia - blood Thalassemia - complications Thalassemia - physiopathology
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Beschreibung
Zusammenfassung:	The clinical manifestations in homozygous thalassemia may be attributed to the defect in hemoglobin synthesis (Figure 16). It is best typified by beta thalassemia, where excess alpha chains accumulate to form intracytoplasmic erythrocytic inclusions. This leads to anemia, bone marrow hyperplasia, osteoporosis, hemosiderosis, and organ failure.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.1980.tb33669.x