The effect of psychoactive drugs on beta-adrenergic receptor binding sites in rat brain
The effect of a variety of psychotropic drugs, given to rats repeatedly over 16 days, on the number of beta-adrenergic receptor binding sites in cerebral cortex was measured. Labelled dihydroalprenolol, [ 3H]-DHA, was used to measure beta-adrenergic binding sites. Both tricyclic antidepressants (ami...
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Veröffentlicht in: | Neuropharmacology 1980-05, Vol.19 (5), p.447-454 |
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Sprache: | eng |
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Zusammenfassung: | The effect of a variety of psychotropic drugs, given to rats repeatedly over 16 days, on the number of beta-adrenergic receptor binding sites in cerebral cortex was measured. Labelled dihydroalprenolol, [
3H]-DHA, was used to measure beta-adrenergic binding sites. Both tricyclic antidepressants (amitriptyline, chlorimipramine, desmethylimipramine and nortriptyline) and monoamine oxidase inhibitors (nialamide and tranylcypromine) lowered [
3H]-DHA binding significantly. Repeated treatment of rats with the antidepressant. iprindole. produced the same effect as did treatment with bupropion. However, the experimental antidepressant mianserin did not reduce [
3H]-DHA binding nor did 11 other psychoactive compounds including chlorpromazine, diazepam,
l-DOPA, tripelennamine and cocaine. The reduction in [
3H]-DHA binding produced by nialamide or iprindole treatment was due to a reduction in the maximum number of beta-adrenergic receptor binding sites. Drug treatment-induced lowering of [
3H]-DHA binding sites in cerebral cortex appears to have utility as a pre-clinical test for antidepressant drugs. |
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ISSN: | 0028-3908 1873-7064 |
DOI: | 10.1016/0028-3908(80)90052-0 |