Radiosensitivity of mouse lung cells measured using an in vitro colony method

We have detailed a method for the study of mouse lung cell clonogenicity in vitro, in which the average plating efficiency was 9%. When we used this method to study the inherent radiosensitivity of lung cells irradiated either in vivo or in vitro (18 hr after seeding), we found that the radiosensiti...

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Veröffentlicht in:	Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1980-04, Vol.6 (4), p.441-447
Hauptverfasser:	Guichard, Marcelle, Deschavanne, Patrick J., Malaise, Edmond-Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	551000 - Physiological Systems 560121 - Radiation Effects on Cells- External Source- (-1987) ALKALI METAL ISOTOPES ANIMAL CELLS ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOASSAY BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY CELL CULTURES Cell Survival Cells, Cultured CESIUM 137 CESIUM ISOTOPES CLONE CELLS CLONING Clonogenic assay COMPARATIVE EVALUATIONS DOSE-RESPONSE RELATIONSHIPS DOSES EXTERNAL IRRADIATION Female IN VITRO IRRADIATION ISOTOPES Lung Lung - pathology Lung - radiation effects LUNGS Male MAMMALS MICE NUCLEI ODD-EVEN NUCLEI ORGANS RADIATION DOSES RADIATION EFFECTS Radiation Tolerance RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOSENSITIVITY RESPIRATORY SYSTEM RESPIRATORY TRACT CELLS RODENTS SURVIVAL CURVES VERTEBRATES X-Rays YEARS LIVING RADIOISOTOPES
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Zusammenfassung:	We have detailed a method for the study of mouse lung cell clonogenicity in vitro, in which the average plating efficiency was 9%. When we used this method to study the inherent radiosensitivity of lung cells irradiated either in vivo or in vitro (18 hr after seeding), we found that the radiosensitivity of mouse lung cells was comparable to that of a large number of mammalian cell lines.
ISSN:	0360-3016 1879-355X
DOI:	10.1016/0360-3016(80)90058-9