The Influence of Bovine Thymus Hypocalcemic Protein, TP1, on the Levels of Cyclic Nucleotides in Murine Thymus Lymphocytes

The effects of bovine thymus hypocalcemic protein (TP1) on cAMP and cGMP levels in murine thymus cells were studied. TP1 elevated cGMP levels 12.5-fold at a concentration of 0.15 mg/ml after incubation for 5 min but the amount of cAMP in thymocytes was lowered. These results suggest that TP1 stimula...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1980/02/25, Vol.28(2), pp.413-416
Hauptverfasser:	HIRAMATSU, REIJI, MIZUTANI, TAKAHARU, MIZUTANI, AKIRA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - pharmacology Cattle Cyclic AMP - metabolism Cyclic GMP - metabolism Mice T-Lymphocytes - drug effects T-Lymphocytes - metabolism thymic hormone Thymus Hormones - pharmacology
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container_title	Chemical & pharmaceutical bulletin
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creator	HIRAMATSU, REIJI MIZUTANI, TAKAHARU MIZUTANI, AKIRA
description	The effects of bovine thymus hypocalcemic protein (TP1) on cAMP and cGMP levels in murine thymus cells were studied. TP1 elevated cGMP levels 12.5-fold at a concentration of 0.15 mg/ml after incubation for 5 min but the amount of cAMP in thymocytes was lowered. These results suggest that TP1 stimulates the differentiation of early T-cells to mature T-cell subsets, such as helper cells, but does not stimulate that of stem cells to early T-cells.
doi_str_mv	10.1248/cpb.28.413
format	Article
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TP1 elevated cGMP levels 12.5-fold at a concentration of 0.15 mg/ml after incubation for 5 min but the amount of cAMP in thymocytes was lowered. 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subjects	Animals Calcium - pharmacology Cattle Cyclic AMP - metabolism Cyclic GMP - metabolism Mice T-Lymphocytes - drug effects T-Lymphocytes - metabolism thymic hormone Thymus Hormones - pharmacology
title	The Influence of Bovine Thymus Hypocalcemic Protein, TP1, on the Levels of Cyclic Nucleotides in Murine Thymus Lymphocytes
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