The Influence of Bovine Thymus Hypocalcemic Protein, TP1, on the Levels of Cyclic Nucleotides in Murine Thymus Lymphocytes

The Influence of Bovine Thymus Hypocalcemic Protein, TP1, on the Levels of Cyclic Nucleotides in Murine Thymus Lymphocytes

The effects of bovine thymus hypocalcemic protein (TP1) on cAMP and cGMP levels in murine thymus cells were studied. TP1 elevated cGMP levels 12.5-fold at a concentration of 0.15 mg/ml after incubation for 5 min but the amount of cAMP in thymocytes was lowered. These results suggest that TP1 stimula...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 1980/02/25, Vol.28(2), pp.413-416
Hauptverfasser: HIRAMATSU, REIJI, MIZUTANI, TAKAHARU, MIZUTANI, AKIRA
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Calcium - pharmacology
Cattle
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Mice
T-Lymphocytes - drug effects
T-Lymphocytes - metabolism
thymic hormone
Thymus Hormones - pharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The effects of bovine thymus hypocalcemic protein (TP1) on cAMP and cGMP levels in murine thymus cells were studied. TP1 elevated cGMP levels 12.5-fold at a concentration of 0.15 mg/ml after incubation for 5 min but the amount of cAMP in thymocytes was lowered. These results suggest that TP1 stimulates the differentiation of early T-cells to mature T-cell subsets, such as helper cells, but does not stimulate that of stem cells to early T-cells.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.28.413