Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in vitro
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1980-07, Vol.209 (4454), p.394-396 |
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| container_issue | 4454 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 209 |
| creator | Pepper, Christine M. Henderson, Graeme |
| description | Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance. |
| doi_str_mv | 10.1126/science.7384811 |
| format | Article |
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Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7384811</identifier><identifier>PMID: 7384811</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Action potentials ; Animals ; Brain ; Central nervous system ; Endorphins - pharmacology ; Enkephalin, Methionine - analogs & derivatives ; Enkephalins - pharmacology ; Guinea Pigs ; Locus coeruleus ; Locus Coeruleus - drug effects ; Locus Coeruleus - physiology ; Membrane Potentials - drug effects ; Morphine ; Morphine Derivatives - pharmacology ; Naloxone - pharmacology ; Nerves ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Opiates ; Opioid peptides ; P branes</subject><ispartof>Science (American Association for the Advancement of Science), 1980-07, Vol.209 (4454), p.394-396</ispartof><rights>Copyright 1980 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c258t-c150a48a9dab706088b6870b937e548544bc9dbf98847cb0f5861afe2abd10593</citedby><cites>FETCH-LOGICAL-c258t-c150a48a9dab706088b6870b937e548544bc9dbf98847cb0f5861afe2abd10593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1684768$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1684768$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7384811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pepper, Christine M.</creatorcontrib><creatorcontrib>Henderson, Graeme</creatorcontrib><title>Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in vitro</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1980-07, Vol.209 (4454), p.394-396 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75145646 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Action potentials Animals Brain Central nervous system Endorphins - pharmacology Enkephalin, Methionine - analogs & derivatives Enkephalins - pharmacology Guinea Pigs Locus coeruleus Locus Coeruleus - drug effects Locus Coeruleus - physiology Membrane Potentials - drug effects Morphine Morphine Derivatives - pharmacology Naloxone - pharmacology Nerves Neurons Neurons - drug effects Neurons - physiology Opiates Opioid peptides P branes |
| title | Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in vitro |
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