Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in vitro

Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1980-07, Vol.209 (4454), p.394-396
Hauptverfasser:	Pepper, Christine M., Henderson, Graeme
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potentials Animals Brain Central nervous system Endorphins - pharmacology Enkephalin, Methionine - analogs & derivatives Enkephalins - pharmacology Guinea Pigs Locus coeruleus Locus Coeruleus - drug effects Locus Coeruleus - physiology Membrane Potentials - drug effects Morphine Morphine Derivatives - pharmacology Naloxone - pharmacology Nerves Neurons Neurons - drug effects Neurons - physiology Opiates Opioid peptides P branes
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Beschreibung
Zusammenfassung:	Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7384811