Derivatives of 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine as central nervous system agents

Four 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepines were prepared and evaluated as central nervous system agents. All were active psychotropic agents as determined by animal screening tests. The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, showed dual...

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Veröffentlicht in:	Journal of medicinal chemistry 1980-04, Vol.23 (4), p.462-465
Hauptverfasser:	Wright, William B, Greenblatt, Eugene N, Day, Ivana P, Quinones, Nicanor Q, Hardy, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - chemical synthesis Anti-Anxiety Agents - pharmacology Antidepressive Agents - chemical synthesis Antipsychotic Agents - chemical synthesis Benzodiazepines Dextroamphetamine - antagonists & inhibitors Mice Motor Activity - drug effects Psychotropic Drugs - chemical synthesis Psychotropic Drugs - pharmacology Rats Structure-Activity Relationship Tetrabenazine - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Four 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepines were prepared and evaluated as central nervous system agents. All were active psychotropic agents as determined by animal screening tests. The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. amphetamine lethality in grouped mice.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00178a020